Myeloid-derived suppressor cells (MDSCs) play roles in immune regulation during\nneoplastic and non-neoplastic inflammatory responses. This immune regulatory function is directed\nmainly toward T cells. However, MDSCs also regulate other cell populations, including B cells, during\ninflammatory responses. Indeed, B cells are essential for antibody-mediated immune responses.\nMDSCs regulate B cell immune responses directly via expression of effector molecules and indirectly\nby controlling other immune regulatory cells. B cell-mediated immune responses are a major\ncomponent of the overall immune response; thus, MDSCs play a prominent role in their regulation.\nHere, we review the current knowledge about MDSC-mediated regulation of B cell responses.
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